Chromatography

Co-Sense for BA features the dilution bypass added in the sample introduction flow channel leading to the MAYI pretreatment columns. Different type of MAYI columns enable to use this approach for various type of components. This dilution bypass eliminates the need for preliminary dilution of the sample by automatically diluting it on-line. Use of a buffer solution as the sample introduction mobile phase or adding a small amount of organic solvent to it ensures effective trapping and concentration of even drugs with a high rate of protein binding, leading to highly efficient deproteinisation and a high recovery rate. Thus, direct injection of unprocessed blood plasma or blood serum has become possible.

HPLC is widely employed in the analysis of drugs within bio-samples. Conditions of the sample pretreatment, as well as chromatographic conditions, are important factors that significantly affect the accuracy and sensitivity of the analysis. Co-Sense for BA, with its unique configuration comprised of the newly developed MAYI-ODS on-line SPE column and the on-line dilution flow channel, automatically and seamlessly conducts all processes from sample pretreatment to analysis. On-line pretreatment of bio-samples such as blood serum or plasma will remarkably enhance the efficiency, as well as reduce the labor, of the analysis.