Liquid Chromatograph-Mass Spectrometry
Liquid Chromatograph-Mass Spectrometry
Shimadzu Liquid Chromatography Mass Spectrometry (LC-MS)
Discover Liquid Chromatography Mass Spectrometry (LC-MS) Solutions from Shimadzu Benelux
Liquid chromatography mass spectrometry (LC-MS) is an essential analytical tool for both quantitative and qualitative analysis across various fields, including pharmaceuticals, food science, and environmental testing.
At Shimadzu, we offer a diverse selection of world-class LC-MS instruments designed to meet your analytical needs. Whether you aim to maximize throughput, enhance sensitivity for trace compound detection, or require a compact LC/MS system for smaller laboratory spaces without compromising workflow efficiency, we have the perfect solution for you.
Our LC-MS product portfolio includes:
- Single Quadrupole (SQ) LC-MS: Ideal for routine analysis with reliable performance.
- Triple Quadrupole (TQ) LC-MS/MS: Perfect for high-sensitivity quantification and complex sample analysis.
- Quadrupole Time-of-Flight (Q-TOF) LC-MS/MS: Offers advanced capabilities for detailed molecular characterization.
Unique automation features and user-friendly software ensure a seamless analysis experience, catering to both beginners and experienced users alike.
Explore Shimadzu's complete range of LC-MS products below and elevate your analytical capabilities today
LC‑MS / LC‑MS/MS – Frequently Asked Questions
What is LC‑MS?
Liquid Chromatography Mass Spectrometry (LC‑MS) combines chromatographic separation with mass‑based detection, enabling sensitive and selective analysis of complex samples.
What is the difference between LC‑MS and LC‑MS/MS?
LC‑MS uses a single mass analyzer, while LC‑MS/MS (tandem MS) uses multiple quadrupoles for highly selective quantitation and lower detection limits.
Which LC‑MS instruments does Shimadzu offer?
Triple Quadrupole: LCMS‑8045, LCMS‑8050, LCMS‑8060NX
High‑Resolution QTOF: LCMS‑9030, LCMS‑9050
Single Quadrupole: LCMS‑2050
What ionization techniques are used?
ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization), and Shimadzu’s DUIS™ dual‑ionization system that allows ESI + APCI in a single method.
What applications is LC‑MS used for?
Pharmaceuticals, clinical research, environmental pollutants (PFAS, pesticides), food safety contaminants, metabolomics, lipidomics, and biomolecule characterization.
What is polarity switching?
The ability to switch rapidly between positive and negative ion detection. Shimadzu systems achieve switching times as low as 5 ms.
How can I optimize sensitivity?
Use LC‑MS‑grade solvents, optimize source parameters, minimize dead volume, maintain the ion source regularly, and ensure chromatographic separation is robust.
What software is used for Shimadzu LC‑MS?
LabSolutions LCMS for instrument control, quantitation, qualitative analysis, compliance, and automated tuning/calibration.
What maintenance does LC‑MS require?
Daily spray checks, weekly ion‑source cleaning, periodic vacuum system inspections, column care, and routine mass calibration.
