Liquid Chromatography
Liquid Chromatography
Liquid Chromatography Systems for High-Performance Laboratory Analysis
Shimadzu Benelux offers advanced Liquid Chromatography (LC) systems designed to meet the analytical demands of modern laboratories. Our portfolio includes High-Performance Liquid Chromatography (HPLC), Ultra High-Performance Liquid Chromatography (UHPLC), Supercritical Fluid Chromatography (SFC), Preparative HPLC Systems, Ion Chromatography Systems, and application-specific chromatography solutions for a wide range of industries. These technologies support accurate separation, identification, and quantification of compounds in complex samples while delivering exceptional sensitivity, reproducibility, and reliability.
Liquid chromatography is one of the most widely used analytical techniques for pharmaceutical analysis, biopharmaceutical research, food safety testing, environmental analysis, chemical analysis, clinical research, and life science applications. Shimadzu LC instruments help laboratories improve analytical accuracy, streamline workflows, and meet stringent regulatory requirements in both research and routine quality control environments.
Our chromatography portfolio includes advanced HPLC systems, UHPLC systems, analytical LC platforms, preparative chromatography systems, and specialized solutions for method development and high-throughput analysis. Combined with innovative automation technologies, Shimadzu instruments help laboratories increase productivity, reduce downtime, and improve operational efficiency.
To maximize performance, Shimadzu also offers a complete range of LC columns, chromatography consumables, sample preparation solutions, vials and accessories, and powerful laboratory software for data acquisition, data processing, compliance, and reporting. Integrated solutions enable laboratories to optimize every stage of the analytical workflow, from sample preparation to result interpretation.
Shimadzu chromatography systems are trusted worldwide for applications including:
- Drug development and pharmaceutical quality control
- Biomolecule and protein analysis
- Environmental contaminant monitoring
- PFAS analysis
- Food and beverage testing
- Clinical and forensic analysis
- Chemical and petrochemical analysis
- Academic and scientific research
Supported by experienced application specialists and service engineers throughout the Benelux region, Shimadzu helps laboratories implement reliable chromatography solutions that deliver precise analytical results and long-term operational performance. Explore our complete range of Liquid Chromatography systems and discover innovative analytical instruments designed to support the future of laboratory science.
Liquid Chromatography (LC) — Frequently Asked Questions
Quick answers on models, methods, maintenance, and compliance.
What is Liquid Chromatography?
Liquid Chromatography separates components in a liquid sample using a stationary phase (column) and mobile phase (solvent), enabling qualitative and quantitative analysis across industries.
What components make up a Shimadzu LC system?
- Pump (isocratic/gradient)
- Autosampler (low carryover, temperature control)
- Column oven (stable temperature)
- Detector(s) (UV/Vis, PDA, FL, RI, etc.)
- LabSolutions CDS (control, acquisition, processing, compliance)
Which applications are typical?
Pharma/biopharma (assay, impurities, peptides/proteins), food & environment (contaminants, pesticides), and industrial/materials (additives, polymers). LC‑MS/MS expands sensitivity/selectivity.
How do I choose the right model?
Match pressure/flow and detector needs to your method, consider throughput and sample matrix, and ensure LabSolutions compliance features match your regulatory requirements.
Can LC integrate with mass spectrometry?
Yes—Shimadzu LC interfaces with LC‑MS/MS for targeted quantitation and trace analysis in complex matrices.
Tips for better peak shape & reproducibility
- Degas and refresh solvents
- Condition the column properly
- Optimize gradient & dwell volume
- Control oven temperature
- Maintain needle/loop cleanliness
Common causes of baseline noise/drift
- Contaminated mobile phases or bubbles
- Dirty detector flow cell
- Insufficient temperature equilibration
- Lamp aging (UV/PDA)
How to reduce carryover
- Configure strong/weak needle washes
- Use low‑adsorption vials/tubing
- Choose appropriate sample diluents
Recommended maintenance schedule
- Daily/weekly: leak check, purge pumps, rinse lines
- Monthly: seals inspection, needle seat clean, strong solvent flush
- Quarterly: check valves/lamp/tubing; backflush columns (if allowed)
How LabSolutions supports compliance
Role-based access, electronic signatures, audit trails, centralized DB—supporting data integrity (e.g., 21 CFR Part 11). Unified LC/GC/LCMS workflows streamline operation.
Consumables & accessories to keep on hand
All Shimadzu Liquid Chromatography (LC) Instruments
